Biotransformation phase 1 Sep. 9 2024.md

1. Ca is a swedish word, do not need to care.
2. 5% means 5% transform, and also means 5% of population lack this transform ability.
3. N-acetylcysteine can be used to cure alcohol toxicity to liver

Points

1. Which are the characteristics of cytochrome P450s? Localization? Function?

2. On what different levels are cytochrome P450 enzymes regulated? How are they regulated?

3. What is metabolic activation?

4. Alcohol has a synergistic effect on paracetamol induced liver toxicity. What is the mechanism behind this?

5. Knock-out mice can sometimes be used for the investigation of routes for formation of toxic metabolites. Exemplify this.

6. In vitro systems for testing hepatotoxicity. Factors to consider!