Gene-environment interactions Sep. 16 2024
Points
- Genetic variation is important for how we respond to a toxic environment
- Variation in genes influencing the toxicokinetics and toxicodynamics of toxicants that we inhale, drink, eat, or get on our skin, influences the susceptibility to toxicity and disease
- Rare mutations causing severe syndromes or GWAS can guide to genes of relevance for susceptibility
- Multiple genes of relevance for susceptibility and the causal variants may vary between populations