Adverse outcome pathways Sep. 17 2024

Points

1. What is an Adverse Outcome Pathway (AOP)?
   A conceptual framework that portrays existing knowledge concerning the key events (KE) that causally link a molecular initiating event (MIE) to an adverse outcome (AO).

2. The five AOP principles

   1. AOPs are not chemical-specific
   2. AOPs are modular and composed of reusable components
   3. An AOP is a pragmatic unit of development and evaluation
   4. For most real‐world applications, AOP networks are the functional units of prediction
   5. AOPs are living documents

3. AOPs can be used for, e.g:

   • Structuring current knowledge and integrating different types of data
   • Identifying data gaps
   • Predicting toxicity based on mechanistic knowledge
   • Strategic planning and testing, IATA
   • Support development of new toxicity test methods.
   • Investigating how chemicals in a mixture may interact