Toxicology of NSAIDs Sep. 13 2024

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Points

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and decreases inflammation
  • It mediates its action via inhibition of cyclooxygenase (COX) enzyme(s) which disrupts the formation of prostanoids
  • Main side/toxicological-effects are gastrointestinal problems, cardiovascular events, kidney disease and associated with hypersensitivity reactions
  • COX-1 inhibitors will increase GI adverse effects
  • COX-2 inhibitors will increase cardiovascular risk